Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_19
Snippet: We observed similar region in the hCoV genomes studied (23713-23724 region in nucleotide alignment), although there was mutation in two hCoV-England nucleotide sequences (CTCCGCGGCGGG in place of CTCCTCGGCGGG) but the resulting amino acid remained same in all hCoV genomes. These findings corroborate the essentiality of RRAR sequence for viral infection to host system. We found different type of mutation in hCoV spike protein at different places s.....
Document: We observed similar region in the hCoV genomes studied (23713-23724 region in nucleotide alignment), although there was mutation in two hCoV-England nucleotide sequences (CTCCGCGGCGGG in place of CTCCTCGGCGGG) but the resulting amino acid remained same in all hCoV genomes. These findings corroborate the essentiality of RRAR sequence for viral infection to host system. We found different type of mutation in hCoV spike protein at different places such as leucine to valine (L8V), glutamine to histidine (Q675H and also found in ORF3a:Q57H), glutamine to lysine (Q239K) and aspartate to glycine (D614G and also found in ORF5, D3G) might have potential role to augment viral infection (Table 5) .
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