Author: Kenneth Lyon; Luis U. Aguilera; Tatsuya Morisaki; Brian Munsky; Timothy J. Stasevich
Title: Live-cell single RNA imaging reveals bursts of translational frameshifting Document date: 2018_11_24
ID: 4fm1skgh_127
Snippet: A new ribosome can initiate translation at the start codon at rate kini. (ii) An existing ribosome can elongate at rate ke to incorporate one amino acid into the nascent peptide chain. The rate ke is sequence-specific with each codon's rate scaled by the genomic copy of the corresponding codon (Nakamura et al., 1999) . When the ribosome completes the final amino acid, translation is terminated and that ribosome is eliminated. (iii) A ribosome at .....
Document: A new ribosome can initiate translation at the start codon at rate kini. (ii) An existing ribosome can elongate at rate ke to incorporate one amino acid into the nascent peptide chain. The rate ke is sequence-specific with each codon's rate scaled by the genomic copy of the corresponding codon (Nakamura et al., 1999) . When the ribosome completes the final amino acid, translation is terminated and that ribosome is eliminated. (iii) A ribosome at the frameshift sequence can shift from the 0 to the -1 frame. In addition to these three reactions, ribosomes at the frameshift sequence can pause for an average time of 1/ * or 1/ for the shifted and non-shifted states. For the bursting model, each RNA is assumed to switch back and forth between non-frameshifting and frameshifting states with rates and . With these mechanisms and parameters, the models can be analyzed using either simplified approximations or detailed simulations.
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