Author: Ming Zhong; Aijun Sun; Ting Xiao; Ge Yao; Ling Sang; Xia Zheng; Jinyan Zhang; Xuejuan Jin; Lei Xu; Wenlong Yang; Peng Wang; Kai Hu; Dingyu Zhang; Junbo Ge
Title: A Randomized, Single-blind, Group sequential, Active-controlled Study to evaluate the clinical efficacy and safety of a-Lipoic acid for critically ill patients with coronavirus disease 2019(COVID-19) Document date: 2020_4_21
ID: mvsnybbo_39
Snippet: The protection efficiency of ALA in critically ill COVID-19 patients might be explained in two aspects, antioxidant and anti-inflammation. Firstly, ALA could ameliorate virus-induced organ dysfunction by counteracting ROS. Ross [14] revealed that excessive superoxide induced by influenza A virus infection could cause organ injury, which could be alleviated by inhibiting ROS production. Besides, Xian and . CC-BY-NC-ND 4.0 International license It .....
Document: The protection efficiency of ALA in critically ill COVID-19 patients might be explained in two aspects, antioxidant and anti-inflammation. Firstly, ALA could ameliorate virus-induced organ dysfunction by counteracting ROS. Ross [14] revealed that excessive superoxide induced by influenza A virus infection could cause organ injury, which could be alleviated by inhibiting ROS production. Besides, Xian and . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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