Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism Document date: 2020_3_25
ID: 1zk64gsg_83
Snippet: To a solution of the allylic acetate 10 (56 mg, 0.13 mmol, 1 equiv.) in 95% ethanol (4 ml) and cyclohexene (2 ml) was added 20 w% Pd(OH)2 on carbon (20mg, 1:3 catalyst substrate by weight). The resulting suspension was stirred under reflux overnight. The reaction mixture was then filtered, concentrated, and dried under high vacuum to afford 20 mg crude material as pale-yellow oil. In a similar manner as the preparation of 9, 6 mg of the crude pro.....
Document: To a solution of the allylic acetate 10 (56 mg, 0.13 mmol, 1 equiv.) in 95% ethanol (4 ml) and cyclohexene (2 ml) was added 20 w% Pd(OH)2 on carbon (20mg, 1:3 catalyst substrate by weight). The resulting suspension was stirred under reflux overnight. The reaction mixture was then filtered, concentrated, and dried under high vacuum to afford 20 mg crude material as pale-yellow oil. In a similar manner as the preparation of 9, 6 mg of the crude product was treated with 25 µL HCl in 250 µL THF to afford the final product 11 (8 mg, 0.037 mmol, 28% for two steps) as white solid.
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