Author: Gytis Dudas; Luiz Max Carvalho; Andrew Rambaut; Trevor Bedford; Ali M. Somily; Mazin Barry; Sarah S. Al Subaie; Abdulaziz A. BinSaeed; Fahad A. Alzamil; Waleed Zaher; Theeb Al Qahtani; Khaldoon Al Jerian; Scott J.N. McNabb; Imad A. Al-Jahdali; Ahmed M. Alotaibi; Nahid A. Batarfi; Matthew Cotten; Simon J. Watson; Spela Binter; Paul Kellam
Title: MERS-CoV spillover at the camel-human interface Document date: 2017_8_10
ID: 8xcplab3_48
Snippet: Here, we employ a Monte Carlo simulation approach to identify parameters consistent with observed patterns of sequence clustering ( Figure S6 ). Our structured coalescent analyses indicate that every MERS outbreak is a contained cross-species spillover of the virus from camels into humans. The distribution of the number of these cross-species transmissions and their sizes thus contain information about the underlying transmission process. At hear.....
Document: Here, we employ a Monte Carlo simulation approach to identify parameters consistent with observed patterns of sequence clustering ( Figure S6 ). Our structured coalescent analyses indicate that every MERS outbreak is a contained cross-species spillover of the virus from camels into humans. The distribution of the number of these cross-species transmissions and their sizes thus contain information about the underlying transmission process. At heart, we expect fewer larger clusters if fundamental reproductive number R 0 is large and more smaller clusters if R 0 is small. A similar approach was used in Grubaugh et al. (2017) to estimate R 0 for Zika introductions into Florida.
Search related documents:
Co phrase search for related documents- cross species transmission and reproductive number: 1
- large cluster and reproductive number: 1
- large cluster and small large cluster: 1
- observed pattern and similar approach: 1, 2
- reproductive number and simulation approach: 1, 2, 3
- similar approach and simulation approach: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date