Monocytes could be a bridge from inflammation to thrombosis on COVID‐19 injury: a case report

Mazzone, Antonino; Castelnovo, Laura; Tamburello, Antonio; Gatti, Arianna; Brando, Bruno; Faggioli, Paola; Mumoli, Nicola

• Inflammation and thrombotic events are frequent but also coronary thrombosis occurring during acute coronary syndromes are due to an inflammatory storm with increased number of circulating activated monocytes/macrophages. • We have mapped the expression of CD11b/CD18 in monocytes/macrophages of a COVID19 patient. • In vivo acute inflammatory response, induced by the virus, and the subsequent cytokine release stimulates the up-regulation of CD11b/CD18 that favors thrombosis. • The overproduction of early response proinflammatory results in an inflammatory storm, leading to an increased risk of vascular hyperpermeability, multiorgan failure, and death. • Advances in cytokine biology and molecular biology have led to the development of novel immunologic approaches to the treatment of COVID19 lung injury that target the cytokine. • Increasing expression of CD11b/CD18 induced by COVID19 play a key role in in bridging inflammation and thrombosis.