Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial

Huijie Bian; Zhao-Hui Zheng; Ding Wei; Zheng Zhang; Wen-Zhen Kang; Chun-Qiu Hao; Ke Dong; Wen Kang; Jie-Lai Xia; Jin-Lin Miao; Rong-Hua Xie; Bin Wang; Xiu-Xuan Sun; Xiang-Min Yang; Peng Lin; Jie-Jie Geng; Ke Wang; Hong-Yong Cui; Kui Zhang; Xiao-Chun Chen; Hao Tang; Hong Du; Na Yao; Shuang-Shuang Liu; Lin-Na Liu; Zhe Zhang; Zhao-Wei Gao; Gang Nan; Qing-Yi Wang; Jian-Qi Lian; Zhi-Nan Chen; Ping Zhu

Chest radiographic analysis was performed independently by two radiologists, and graded by the changed areas of ground-glass opacity and consolidation compared with the baseline. As shown in figure 3 , the chest radiographic, compared to baseline in both two groups, were improved gradually over 28 days. At day 7, in the meplazumab group, 1 case (5.9%, 1/17) improved more than 50%, and 7 cases (41.2%, 7/17) improved 25-50%, while no patients improved over 25% in control group. At day 14, 47.1% patients (8/17) in meplazumab group improved more than 50%, and no similar situation was observed in control group. At day 21, 12 case (70.6%, 12/17) improved more than 50%, and 3 cases (17.6%, 3/17) improved 25-50% in meplazumab group, while 3 case (27.3%, 3/11) improved more than 50%, and 5 cases (45.5%, 5/11) improved 25-50% in control group. The meplazumab group showed more significant benefit than control group in days 7, 14, and 21 (p=0.010, p=0.006, and p=0.037, respectively), which coincident with the improvement of case severity. A representative chest CT image of meplazumab-treated patient was shown in figure 4 , which displayed the CT imaging All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.