Author: Huijie Bian; Zhao-Hui Zheng; Ding Wei; Zheng Zhang; Wen-Zhen Kang; Chun-Qiu Hao; Ke Dong; Wen Kang; Jie-Lai Xia; Jin-Lin Miao; Rong-Hua Xie; Bin Wang; Xiu-Xuan Sun; Xiang-Min Yang; Peng Lin; Jie-Jie Geng; Ke Wang; Hong-Yong Cui; Kui Zhang; Xiao-Chun Chen; Hao Tang; Hong Du; Na Yao; Shuang-Shuang Liu; Lin-Na Liu; Zhe Zhang; Zhao-Wei Gao; Gang Nan; Qing-Yi Wang; Jian-Qi Lian; Zhi-Nan Chen; Ping Zhu
Title: Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial Document date: 2020_3_24
ID: 6g34qwer_33
Snippet: In meplazumab group, the elevation of both ALT and AST (≥ 2 ULN ) was reported in 2 patients (2/17, 11.8%). In control group, both ALT and AST elevations were reported in 1 case (9.1%), and single ALT elevation was reported in 1 case (9.1%). The increased level of ALT and AST returned to normal after 7 days in all four patients, and the treatment procedure was not affected by their fluctuation. The abnormal transaminase was not related with mep.....
Document: In meplazumab group, the elevation of both ALT and AST (≥ 2 ULN ) was reported in 2 patients (2/17, 11.8%). In control group, both ALT and AST elevations were reported in 1 case (9.1%), and single ALT elevation was reported in 1 case (9.1%). The increased level of ALT and AST returned to normal after 7 days in all four patients, and the treatment procedure was not affected by their fluctuation. The abnormal transaminase was not related with meplazumab treatment after comprehensive judgement by the investigators. No other adverse event was reported in meplazumabtreated patients, including reaction around the injection site, rash, nausea, vomit, anemia, neutropenia, thrombocytopenia, total bilirubin, albumin and creatinine etc.
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