Relationship of substance dependence and time to RT-PCR negative status in patients with COVID-19 infection

Mehra, Aseem; Suri, Vikas; Sahoo, Swapnajeet; Malhotra, Pankaj; Yaddanapudi, Lakshmi Narayana; Puri, G D; Bhalla, Ashish; Grover, Sandeep

BACKGROUND: To date, no study has evaluated the association of alcohol dependence with the outcome of the COVID-19 infection. AIM: The current study aimed to evaluate the association of substance dependence (alcohol and tobacco) with the outcome (i.e., time to have two consecutive negative test reports) of the COVID-19 infection. RESULTS: The mean age of the study participants (n = 95) was 37.2 yrs (SD-13.2). More than half of the participants were males. About one-fourth (N = 25; 26.3%) were consuming various substances in a dependent pattern. Alcohol dependence was present in 21 participants (22.1%), and Tobacco dependence was present in 10.5% of participants. Even after using gender, age, and physical illness as covariates, patients with any kind of substance dependence had a significantly lower chance of having a negative report on RT-PCR on 14th day, 18th 23rd day. CONCLUSION: Substance dependence takes a longer time to test negative on RT-PCR, once diagnosed with COVID-19 infection. Mental health professionals involved in the care of patients with COVID-19 should accordingly prepare these patients for a possible longer hospital stay to reduce the distress associated with prolongation of hospital stay.