Author: Huijie Bian; Zhao-Hui Zheng; Ding Wei; Zheng Zhang; Wen-Zhen Kang; Chun-Qiu Hao; Ke Dong; Wen Kang; Jie-Lai Xia; Jin-Lin Miao; Rong-Hua Xie; Bin Wang; Xiu-Xuan Sun; Xiang-Min Yang; Peng Lin; Jie-Jie Geng; Ke Wang; Hong-Yong Cui; Kui Zhang; Xiao-Chun Chen; Hao Tang; Hong Du; Na Yao; Shuang-Shuang Liu; Lin-Na Liu; Zhe Zhang; Zhao-Wei Gao; Gang Nan; Qing-Yi Wang; Jian-Qi Lian; Zhi-Nan Chen; Ping Zhu
Title: Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial Document date: 2020_3_24
ID: 6g34qwer_38
Snippet: CD147 is a receptor for ligand CyPA, and its interaction with CD147 was key to the inflammation and chemotaxis. 21 CyPA is secreted to extracellular in response to inflammatory stimuli (e.g. virus infection), activates and attracts leukocytes via its receptor CD147 to the stimulus site. 15 We demonstrated that anti-CD147 antibody could attenuate the chemotactic index of T cells induced by CyPA. 17 Multiple cytokines and chemokines increased signi.....
Document: CD147 is a receptor for ligand CyPA, and its interaction with CD147 was key to the inflammation and chemotaxis. 21 CyPA is secreted to extracellular in response to inflammatory stimuli (e.g. virus infection), activates and attracts leukocytes via its receptor CD147 to the stimulus site. 15 We demonstrated that anti-CD147 antibody could attenuate the chemotactic index of T cells induced by CyPA. 17 Multiple cytokines and chemokines increased significantly in patients with COVID-19, which was significantly correlated with pulmonary inflammation index of chest CT imaging. 4.22 These results suggest that the excess immune cells migrating into lung tissue may cause uncontrolled immune response, leading to the inflammation storm, and aggravated disease. We presumed that meplazumab blocked the interaction between CyPA and CD147, attenuated the chemotactic effect of CyPA, decreased the immune cells in lung tissue, and facilitated the improvement of chest radiographic. In this trial, the remarkable and rapid resolution of inflammatory foci in lungs, like ground-glass opacity and consolidation, were observed in meplazumab treatment group.
Search related documents:
Co phrase search for related documents- chemotactic effect and CyPA chemotactic effect: 1
- chemotaxis inflammation and CyPA induce: 1
- chemotaxis inflammation and immune cell: 1, 2, 3, 4, 5
- chemotaxis inflammation and immune response: 1, 2
- chest CT imaging and consolidation ground glass opacity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- chest CT imaging and CT imaging: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chest CT imaging and ground glass: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chest CT imaging and ground glass opacity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chest CT imaging and immune response: 1
- chest radiographic improvement and ground glass: 1
- consolidation ground glass opacity and CT imaging: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- consolidation ground glass opacity and ground glass: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- consolidation ground glass opacity and ground glass opacity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- CT imaging and ground glass: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- CT imaging and ground glass opacity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- CT imaging and immune cell: 1, 2
- CT imaging and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- ground glass and immune cell: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date