Author: Zuo, Yu; Kanthi, Yogendra; Knight, Jason S.; Kim, Alfred H.J.
Title: The interplay between neutrophils, complement, and microthrombi in COVID-19 Cord-id: fhdfbcyr Document date: 2021_1_13
ID: fhdfbcyr
Snippet: As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and, in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the inn
Document: As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and, in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology and highlight potential therapeutic strategies to combat these pathways.
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