Selected article for: "acid oxidation and acute respiratory failure"
Author: Wongkittichote, Parith; Watson, James R.; Leonard, Jennifer M.; Toolan, Elizabeth R.; Dickson, Patricia I.; Grange, Dorothy K.
Title: Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
  • Cord-id: cx8fx9u9
  • Document date: 2020_9_10
    • ID: cx8fx9u9
    Snippet: Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID‐19) is a pandemic caused by the RNA virus SARS‐CoV‐2 with diverse presentations ranging from respiratory symptoms to myocarditis.
    Document: Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID‐19) is a pandemic caused by the RNA virus SARS‐CoV‐2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID‐19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long‐chain fatty acid oxidation disorder.

    Search related documents:
    Co phrase search for related documents
    • abdominal pain and acute cardiomyopathy: 1, 2
    • abdominal pain and acute deterioration: 1
    • abdominal pain and acute kidney injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • abdominal pain and acute kidney injury rhabdomyolysis: 1
    • abdominal pain and acute onset: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
    • abdominal pain and acute respiratory failure: 1, 2, 3, 4, 5, 6
    • abdominal pain and admission 11: 1, 2, 3
    • abdominal pain and admission prior: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • abdominal pain and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • abdominal pain and liver function study: 1, 2
    • abnormal coagulation and acute kidney injury: 1, 2, 3
    • abnormal coagulation and acute respiratory failure: 1, 2
    • abnormal coagulation and admission 11: 1, 2
    • abnormal coagulation and liver function: 1, 2, 3, 4
    • acute cardiomyopathy and admission prior: 1
    • acute cardiomyopathy and liver function: 1
    • acute deterioration and admission 11: 1
    • acute deterioration and admission prior: 1, 2
    • acute deterioration and liver function: 1, 2