Author: Handtke, Stefan; Wolff, Martina; Zaninetti, Carlo; Wesche, Jan; Schönborn, Linda; Aurich, Konstanze; Ulm, Lena; Hübner, Nils-Olaf; Becker, Karsten; Thiele, Thomas; Greinacher, Andreas
Title: A Flow cytometric assay to detect platelet activating antibodies in VITT after ChAdOx1 nCov-19 vaccination Cord-id: rh5xshkr Document date: 2021_5_8
ID: rh5xshkr
Snippet: Vaccination is crucial in combatting the SARS-CoV-2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activating antibodies directed against platelet factor 4. We present a widely applicable whole blood standard flow cytometric assay to identify the pathogenic antibodies associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCov-19 vaccination. This assay will
Document: Vaccination is crucial in combatting the SARS-CoV-2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activating antibodies directed against platelet factor 4. We present a widely applicable whole blood standard flow cytometric assay to identify the pathogenic antibodies associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCov-19 vaccination. This assay will enable rapid diagnosis by many laboratories.
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