Author: Ian M. Silverman; Sager J. Gosai; Nicholas Vrettos; Shawn W. Foley; Nathan D. Berkowitz; Zissimos Mourelatos; Brian D. Gregory
Title: Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo Document date: 2018_4_6
ID: 1pbshnw9_81
Snippet: We also found that the IRE elements of human and mouse ferritin mRNAs are processed into pre-miRNA-like molecules, but rarely into mature AGO-bound smRNA species (Figs. 7 and S8 ). Further processing of theses hairpins may only occur in specific cell types (i.e. blood cells) under stress conditions. Moreover, knockdown of DROSHA or DGCR8 had no effect on the expression of IRE host genes (Fig. 5I) . Then, what is the function of these pre-miRNA-li.....
Document: We also found that the IRE elements of human and mouse ferritin mRNAs are processed into pre-miRNA-like molecules, but rarely into mature AGO-bound smRNA species (Figs. 7 and S8 ). Further processing of theses hairpins may only occur in specific cell types (i.e. blood cells) under stress conditions. Moreover, knockdown of DROSHA or DGCR8 had no effect on the expression of IRE host genes (Fig. 5I) . Then, what is the function of these pre-miRNA-like molecules? IRE hairpins may represent stable remnants of normal degradation of IRE containing mRNAs. However, given the conservation of AGO-associated stem-loops from IREs in both human and mouse cell, this seems unlikely.
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