Author: Andrew J. McNamara; Pranav Danthi
Title: Loss of IKK subunits limits NF-?B signaling in reovirus infected cells Document date: 2019_11_15
ID: e13xm0mh_12
Snippet: Two previous studies have suggested that reovirus limits the innate immune 287 response. Reovirus can inhibit IFN production by sequestering IRF3 into viral factories 288 (39). Additionally, reovirus can inhibit IFN signaling by nuclear sequestration of IRF9, 289 which functions with STAT1 and 2 to promote expression of IFN stimulated genes (40). 290.....
Document: Two previous studies have suggested that reovirus limits the innate immune 287 response. Reovirus can inhibit IFN production by sequestering IRF3 into viral factories 288 (39). Additionally, reovirus can inhibit IFN signaling by nuclear sequestration of IRF9, 289 which functions with STAT1 and 2 to promote expression of IFN stimulated genes (40). 290
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