Author: Haneklaus, M.; Gerlic, M.; O'Neill, L. A. J.; Masters, S. L.
Title: miRâ€223: infection, inflammation and cancer Cord-id: vc1y8g90 Document date: 2013_6_25
ID: vc1y8g90
Snippet: Expression of the microRNA miRâ€223 is deregulated during influenza or hepatitis B infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and lymphoma. Although this may also be the result of the disease per se, increasing evidence suggests a role for miRâ€223 in limiting inflammation to prevent collateral damage during infection and in preventing oncogenic myeloid transformation. Validated targets for miRâ€223 that have effects on inflammation and infection include granzyme
Document: Expression of the microRNA miRâ€223 is deregulated during influenza or hepatitis B infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and lymphoma. Although this may also be the result of the disease per se, increasing evidence suggests a role for miRâ€223 in limiting inflammation to prevent collateral damage during infection and in preventing oncogenic myeloid transformation. Validated targets for miRâ€223 that have effects on inflammation and infection include granzyme B, IKKα, Roquin and STAT3. With regard to cancer, validated targets include C/EBPβ, E2F1, FOXO1 and NFIâ€A. The effect of miRâ€223 on these targets has been documented individually; however, it is more likely that miRâ€223 affects multiple targets simultaneously for key processes where the microRNA is important. Such processes include haematopoietic cell differentiation, particularly towards the granulocyte lineage (where miRâ€223 is abundant) and as cells progress down the myeloid lineage (where miRâ€223 expression decreases). NFâ€ÎºB and the NLRP3 inflammasome are important inflammatory mechanisms that are dampened by miRâ€223 in these cell types. The miRNA can also directly target viruses such as HIV, leading to synergistic effects during infection. Here we review the recent studies of miRâ€223 function to show how it modulates inflammation, infection and cancer development.
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