Author: Spyridon Megremis; Thomas Walker; Xiaotong He; James O'Sullivan; William E.R. Ollier; Hector Chinoy; Neil Pendleton; Antony Payton; Lynne Hampson; Ian Hampson; Janine Lamb
Title: Microbial and autoantibody immunogenic repertoires in TIF1? autoantibody positive dermatomyositis Document date: 2020_3_26
ID: hroxg2u1_12
Snippet: The number of distinct epitopes per microbe (epitopes present in both groups at minimum five-fold enrichment) significantly increased in the P20s compared to P10s in both groups ( Figure 2C ); (n=432, 95%CI: 0.86-0.94) to (n=455, 95%CI: 2.02-2.10) in DM and 432 (n=432, 95%CI: 1.29-1.37) to 448 (n=448, 95%CI: 1.60-1.68) in HC. The unique microbial epitopes which were identified only in one of the two groups significantly increased in DM P20 (n=377.....
Document: The number of distinct epitopes per microbe (epitopes present in both groups at minimum five-fold enrichment) significantly increased in the P20s compared to P10s in both groups ( Figure 2C ); (n=432, 95%CI: 0.86-0.94) to (n=455, 95%CI: 2.02-2.10) in DM and 432 (n=432, 95%CI: 1.29-1.37) to 448 (n=448, 95%CI: 1.60-1.68) in HC. The unique microbial epitopes which were identified only in one of the two groups significantly increased in DM P20 (n=377, 95%CI: 0.69-0.77) compared to DM P10 (n=296, 95%CI: 0.01-0.03) and decreased in HC P20 (n=270, 95%CI: 0.18-0.23) compared to HC P10 (n=348, 95%CI: 0.31-0.36) ( Figure 2E ). Collectively, these data indicate an expansion of the DMspecific microbial diversity with increasing DM plasma sample size, whereas the opposite effect was observed in HC.
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