Author: Spyridon Megremis; Thomas Walker; Xiaotong He; James O'Sullivan; William E.R. Ollier; Hector Chinoy; Neil Pendleton; Antony Payton; Lynne Hampson; Ian Hampson; Janine Lamb
Title: Microbial and autoantibody immunogenic repertoires in TIF1? autoantibody positive dermatomyositis Document date: 2020_3_26
ID: hroxg2u1_29
Snippet: Finally, we aligned all DM-enriched viral and TRIM epitopes ( Figure S7C ) and identified a third epitope "KHKGALGGGGNE" of TRIM47 which is shared by Human immunodeficiency virus 1 "KHKGALGGGG(N)E", and "KHKG(D)LGGGG(Y)E" shared by Synechococcus phage syn9 "KHKG(D)LGGGG(Y)E" ( Figure S7D ). The epitope was poorly conserved amongst the DM-specific TRIM proteins ( Figure 7B ). Overall, we have identified two epitope sequences that are shared betwee.....
Document: Finally, we aligned all DM-enriched viral and TRIM epitopes ( Figure S7C ) and identified a third epitope "KHKGALGGGGNE" of TRIM47 which is shared by Human immunodeficiency virus 1 "KHKGALGGGG(N)E", and "KHKG(D)LGGGG(Y)E" shared by Synechococcus phage syn9 "KHKG(D)LGGGG(Y)E" ( Figure S7D ). The epitope was poorly conserved amongst the DM-specific TRIM proteins ( Figure 7B ). Overall, we have identified two epitope sequences that are shared between Variola virus and TRIM3 but also between members of the Poxviridae family. A third epitope that is shared between TRIM47, HIV-1 and Syn9 was also observed. These findings suggest that molecular mimicry events, at least amongst these specific viral and TRIM epitopes, is a potential mechanism of pathogenesis in DM.
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