Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics Document date: 2018_1_16
ID: dzorkks5_24
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint ( Supplementary Fig. 5b,c) . By contrast, neomycin-treatment of STING knockout mice 222 resulted in robust antiviral protection with significantly suppressed viral replication and little 223 to no disease pathology ( Supplementary Fig. 5e,f) . These results indicate that the cytosolic 224 DNA sensor signaling pathway .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint ( Supplementary Fig. 5b,c) . By contrast, neomycin-treatment of STING knockout mice 222 resulted in robust antiviral protection with significantly suppressed viral replication and little 223 to no disease pathology ( Supplementary Fig. 5e,f) . These results indicate that the cytosolic 224 DNA sensor signaling pathway is dispensable for ISG induction by neomycin, while RNA 225 sensor signaling pathways play a partial role in aminoglycoside-mediated ISG induction. Irf3 -/-Irf7 -/mice as compared to PBS-treated controls (Fig. 4g ) and this lack of ISG 245 induction resulted in lack of protection against HSV-2 infection (Fig. 4h,i) . Induction of 246
Search related documents:
Co phrase search for related documents- antiviral protection and neomycin ISG induction: 1, 2
- antiviral protection and pathway signaling: 1, 2, 3
- antiviral protection and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- disease pathology and pathway signal: 1
- disease pathology and pathway signaling: 1, 2, 3, 4
- disease pathology and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- dna sensor and pathway signal: 1
- dna sensor and pathway signaling: 1, 2, 3, 4, 5
- dna sensor and viral replication: 1
- ISG induction and neomycin ISG induction: 1, 2, 3
- ISG induction and pathway signaling: 1, 2, 3, 4, 5, 6, 7, 8
- ISG induction and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- ISG lack and pathway signaling: 1
- ISG lack and viral replication: 1
- neomycin ISG induction and pathway signaling: 1
- partial role and viral replication: 1
- pathway signal and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- pathway signaling and significantly suppress: 1
- pathway signaling and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
Co phrase search for related documents, hyperlinks ordered by date