Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_2
Snippet: Diagnosis of LRTI in HCT recipients is particularly challenging due to high rates of noninfectious inflammatory conditions such as graft versus host disease (GVHD) that can drive pulmonary inflammation, induce fever and mimic infection (6). Furthermore, the diagnostic yield of traditional tests is reduced in HCT patients due to antimicrobial prophylaxis, reduced antibody titers, and infections from uncommon opportunistic microorganisms (7) ......
Document: Diagnosis of LRTI in HCT recipients is particularly challenging due to high rates of noninfectious inflammatory conditions such as graft versus host disease (GVHD) that can drive pulmonary inflammation, induce fever and mimic infection (6). Furthermore, the diagnostic yield of traditional tests is reduced in HCT patients due to antimicrobial prophylaxis, reduced antibody titers, and infections from uncommon opportunistic microorganisms (7) .
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