Author: Sposito, Benedetta; Broggi, Achille; Pandolfi, Laura; Crotta, Stefania; Ferrarese, Roberto; Sisti, Sofia; Clementi, Nicola; Ambrosi, Alessandro; Liu, Enju; Frangipane, Vanessa; Saracino, Laura; Marongiu, Laura; Facchini, Fabio A; Bottazzi, Andrea; Fossali, Tommaso; Colombo, Riccardo; Clementi, Massimo; Tagliabue, Elena; Pontiroli, Antonio E; Meloni, Federica; Wack, Andreas; Mancini, Nicasio; Zanoni, Ivan
Title: Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients. Cord-id: rvm93xv9 Document date: 2021_3_30
ID: rvm93xv9
Snippet: The COVID-19 outbreak driven by SARS-CoV-2 has caused more than 2.5 million deaths globally, with the most severe cases characterized by over-exuberant production of immune-mediators, the nature of which is not fully understood. Interferons of the type I (IFN-I) or type III (IFN-III) families are potent antivirals, but their role in COVID-19 remains debated. Our analysis of gene and protein expression along the respiratory tract shows that IFNs, especially IFN-III, are over-represented in the lo
Document: The COVID-19 outbreak driven by SARS-CoV-2 has caused more than 2.5 million deaths globally, with the most severe cases characterized by over-exuberant production of immune-mediators, the nature of which is not fully understood. Interferons of the type I (IFN-I) or type III (IFN-III) families are potent antivirals, but their role in COVID-19 remains debated. Our analysis of gene and protein expression along the respiratory tract shows that IFNs, especially IFN-III, are over-represented in the lower airways of patients with severe COVID-19, while high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity; also, IFN expression varies with abundance of the cell types that produce them. Our data point to a dynamic process of inter- and intra-family production of IFNs in COVID-19, and suggest that IFNs play opposing roles at distinct anatomical sites.
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