Author: James T. VanLeuven; Benjamin J. Ridenhour; Craig R. Miller; Tanya A. Miura
Title: Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses Document date: 2016_12_2
ID: iedh762s_5
Snippet: PR8 infection results in a range of disease severities that is mouse strain-dependent [10] . Although susceptible 59 mice mount a type I IFN response to PR8 infection, lethal infection is associated with spread of virus to the 60 alveoli and an excessive inflammatory response [10] [11] [12] [13] . PR8 replicates in bronchiolar and alveolar epithelial 61 cells of the lower respiratory tract in vivo and in primary murine respiratory epithelial cell.....
Document: PR8 infection results in a range of disease severities that is mouse strain-dependent [10] . Although susceptible 59 mice mount a type I IFN response to PR8 infection, lethal infection is associated with spread of virus to the 60 alveoli and an excessive inflammatory response [10] [11] [12] [13] . PR8 replicates in bronchiolar and alveolar epithelial 61 cells of the lower respiratory tract in vivo and in primary murine respiratory epithelial cells in vitro (Blazejewska 62 et al., 2011; [9, 14, 15] .
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