Author: Xuesen Zhao; Shuangli Zheng; Danying Chen; Mei Zheng; Xinglin Li; Guoli Li; Hanxin Lin; Jinhong Chang; Hui Zeng; Ju-Tao Guo
Title: LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2 Document date: 2020_4_5
ID: dxuabscn_2
Snippet: HCoV-OC43 and HCoV-HKU1 bind to 9-Oacetylated sialic acids via a conserved receptor-79 binding site in spike protein domain A to initiate the infection of target cells (19) . As the key 80 determinant of cell tropism, host range, and pathogenesis, CoV entry is primarily controlled by 81 interactions between the spike envelope glycoprotein and host cell receptor as well as the 82 susceptibility of spike glycoprotein to protease cleavage and/or aci.....
Document: HCoV-OC43 and HCoV-HKU1 bind to 9-Oacetylated sialic acids via a conserved receptor-79 binding site in spike protein domain A to initiate the infection of target cells (19) . As the key 80 determinant of cell tropism, host range, and pathogenesis, CoV entry is primarily controlled by 81 interactions between the spike envelope glycoprotein and host cell receptor as well as the 82 susceptibility of spike glycoprotein to protease cleavage and/or acid-induced activation of 83 membrane fusion (20, 21) . For instance, SARS-CoV can use ACE2 orthologs of different animal 84 species as receptors (22) (23) (24) (25) (26) and the efficiency of these ACE2 orthologs to mediate SARS-CoV 85 cell entry is consistent with the susceptibility of these animals to . 86
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