Selected article for: "adult onset and high throughput"
Author: Spyridon Megremis; Thomas Walker; Xiaotong He; James O'Sullivan; William E.R. Ollier; Hector Chinoy; Neil Pendleton; Antony Payton; Lynne Hampson; Ian Hampson; Janine Lamb
Title: Microbial and autoantibody immunogenic repertoires in TIF1? autoantibody positive dermatomyositis
  • Document date: 2020_3_26
    • ID: hroxg2u1_30
    Snippet: . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.007534 doi: bioRxiv preprint Discussion This is the first study to investigate the accumulated microbial and autoantigen antibody repertoire in adult-onset dermatomyositis (DM) patients positive for antibodies against TIF1 (TRIM33). We used an un-targeted .....
    Document: . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.007534 doi: bioRxiv preprint Discussion This is the first study to investigate the accumulated microbial and autoantigen antibody repertoire in adult-onset dermatomyositis (DM) patients positive for antibodies against TIF1 (TRIM33). We used an un-targeted high-throughput approach which combines immunoglobulin disease-specific enrichment of immunogenic epitopes, and subsequent identification of anti-microbial antibody and autoantibody richness and abundance. Key findings include that (1) the DM-specific IgOme was characterised by high microbial diversity, (2) antibodies against viruses were over-represented and species of the Poxviridae family were significantly enriched, (3) DM-specific accumulated autoantibodies target a significant portion of the human proteome, including proteins from specific biological processes and interferon regulated proteins, (4) autoantibodies against TRIM33 and eleven further TRIM proteins were identified, and (5) specific TRIM proteins share epitope homology with viral species identified from the plasma of DM patients.

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