Author: Kuo, Chih-Jung; Liu, Hun-Ge; Lo, Yueh-Kuei; Seong, Churl-Min; Lee, Kee-In; Jung, Young-Sik; Liang, Po-Huang
Title: Individual and common inhibitors of coronavirus and picornavirus main proteases Cord-id: ghpto6nn Document date: 2009_2_4
ID: ghpto6nn
Snippet: Picornaviruses (PV) and coronaviruses (CoV) are positive-stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS-CoV 3CL(pro) with IC(50) of low μM. Interestingly, one of them equally inhibited both 3C(pro) and 3CL(pro) from PV and CoV, respectively. Using computer modeling, the structura
Document: Picornaviruses (PV) and coronaviruses (CoV) are positive-stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS-CoV 3CL(pro) with IC(50) of low μM. Interestingly, one of them equally inhibited both 3C(pro) and 3CL(pro) from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti-viral agents against PV and CoV.
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