Author: Roberts, Anjeanette; Lamirande, Elaine W.; Vogel, Leatrice; Jackson, Jadon P.; Paddock, Christopher D.; Guarner, Jeannette; Zaki, Sherif R.; Sheahan, Timothy; Baric, Ralph; Subbarao, Kanta
Title: Animal Models and Vaccines for SARS-CoV Infection Cord-id: sc1m4c07 Document date: 2008_4_1
ID: sc1m4c07
Snippet: We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV s
Document: We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.
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