Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics Document date: 2018_1_16
ID: dzorkks5_19
Snippet: We previously showed that oral neomycin treatment renders Mx1 deficient mice 181 susceptible to influenza disease because it depletes gut commensal bacteria that normally 182 support the function of dendritic cells that prime CD8 T cells 18 with an otherwise lethal dose of hvPR8, with 50% of mice protected (Fig. 3b) . These 191 results demonstrate that mucosal application of a single dose of neomycin can result in 192 substantial protection again.....
Document: We previously showed that oral neomycin treatment renders Mx1 deficient mice 181 susceptible to influenza disease because it depletes gut commensal bacteria that normally 182 support the function of dendritic cells that prime CD8 T cells 18 with an otherwise lethal dose of hvPR8, with 50% of mice protected (Fig. 3b) . These 191 results demonstrate that mucosal application of a single dose of neomycin can result in 192 substantial protection against a highly virulent influenza A virus infection. 193
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