Author: Abeygunasekera, Anuruddha; Jayasinghe, Saroj
Title: Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? Cord-id: sdih33mv Document date: 2020_5_18
ID: sdih33mv
Snippet: SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammato
Document: SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.
Search related documents:
Co phrase search for related documents- acid metabolism and acute inflammation: 1, 2
- acid metabolism and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acid metabolism and lox lipoxygenase: 1
- acid metabolism and lung inflammation: 1, 2
- acid metabolism and lung injury: 1
- acid related and acute ards respiratory distress syndrome: 1
- acid related and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- acid related and lox lipoxygenase: 1
- acid related and lung inflammation: 1
- acute ards respiratory distress syndrome and local activity: 1, 2
- acute ards respiratory distress syndrome and lox lipoxygenase: 1
- acute ards respiratory distress syndrome and lung inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute ards respiratory distress syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute inflammation and lung inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute inflammation and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute inflammation model and lung inflammation: 1, 2, 3
- acute inflammation model and lung injury: 1
- acute inflammation model study and lung inflammation: 1
- acute inflammation model study and lung injury: 1
Co phrase search for related documents, hyperlinks ordered by date