Selected article for: "epitope prediction and IFN Î release"
Author: M. Shaminur Rahman; M. Nazmul Hoque; M. Rafiul Islam; Salma Akter; A. S. M. Rubayet-Ul-Alam; Mohammad Anwar Siddique; Otun Saha; Md. Mizanur Rahaman; Munawar Sultana; M. Anwar Hossain
Title: Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach
  • Document date: 2020_3_31
    • ID: 0yqyclxk_13
    Snippet: The findings of IFNepitope program suggests that, both the target RBD and NTD regions 242 of S protein, and B-cell linear epitope (MBE) had great probability to release of IFN-γ with a 243 positive score. A total of 56 potential positive IFN-γ inducing epitopes (15-mer) were predicted 244 for the RBD domain with an average epitope prediction score of 0.255 and the maximum SVM 245 score of 0.625. On the other hand, a total of 33 potential positi.....
    Document: The findings of IFNepitope program suggests that, both the target RBD and NTD regions 242 of S protein, and B-cell linear epitope (MBE) had great probability to release of IFN-γ with a 243 positive score. A total of 56 potential positive IFN-γ inducing epitopes (15-mer) were predicted 244 for the RBD domain with an average epitope prediction score of 0.255 and the maximum SVM 245 score of 0.625. On the other hand, a total of 33 potential positive epitopes were predicted for the 246 NTD domain with an average epitope prediction score of 0.312 and the maximum SVM score of 247 0.811. Moreover, the M protein also possessed several IFN-γ inducing epitopes having an 248 average epitope prediction score of 0.980 (Supplementary Table 4 (Fig. 5a, Supplementary Data 2) . In addition to geographical 266 distribution, the ethnic groups also found to be an important determinant for good coverage of 267 the CTL and HTL epitopes (Fig. 5b)

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