A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: a possible reason underlying different outcome between gender.

Fanfan Zeng; Chan Dai; Pengcheng Cai; Jinbiao Wang; Lei Xu; Jianyu Li; Guoyun Hu; Lin Wang

Next, to determine the concentration distribution of SARS-CoV-2 IgG antibody, we analyzed the proportion of the antibody in each range (0-10 AU/mL, 10-100 AU/mL, 100-150AU/mL and 150-200 AU/mL) in male patients and female patients. As is shown in Figure 2A , the proportion of range 0-10 AU/mL were consistent in male and female patients and the proportion of range 100-150 AU/mL was also close between male and female patients. However, the range 10-100AU/mL and 150-200 AU/mL showed great difference between two groups. In range 10-100 AU/mL, the male patients accounted for as much as 63.64%, while the female patient took up 27.27%. In range 150-200 AU/mL, the female patients accounted for as much as 54.55%, while the male patients occupied only 9.09%. Then we divided the severe status patient into two groups (high and low level: 0-100 AU/mL and 100-200 AU/mL) by antibody concentration. The statistical analysis showed that the level of IgG antibody in female patients was of no statistical difference between male and female patients in low level groups, while in high level groups female patients was significantly higher than male patients. These All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.