Author: Lin Li; Ting Sun; Yufei He; Wendong Li; Yubo Fan; Jing Zhang
Title: Epitope-based peptide vaccine design and target site characterization against novel coronavirus disease caused by SARS-CoV-2 Document date: 2020_2_27
ID: e9vq3fe3_3
Snippet: Structural proteins are important targets for vaccine and anti-viral drug development due to their indispensable function to fuse and enter into the host cell [8] . SARS-CoV-2 utilizes glycosylated spike (S) protein to gain entry into host cells. The S protein is a trimeric class I fusion protein and exists in a metastable prefusion conformation that undergoes a dramatic structural rearrangement to fuse the viral membrane with the host-cell membr.....
Document: Structural proteins are important targets for vaccine and anti-viral drug development due to their indispensable function to fuse and enter into the host cell [8] . SARS-CoV-2 utilizes glycosylated spike (S) protein to gain entry into host cells. The S protein is a trimeric class I fusion protein and exists in a metastable prefusion conformation that undergoes a dramatic structural rearrangement to fuse the viral membrane with the host-cell membrane [1, 9, 10] . The S protein includes the receptor binding S1-subunit and the membrane fusion S2-subunit. The S1 subunit receptor-binding domain (RDB) is specifically recognized by the host receptor. When the S1 subunit binds to a host-cell receptor, the prefusion trimer is destabilized, resulting in the shedding of S1 subunit, and the state transition of S2 subunit to a stable postfusion conformation [11] . The critical function of the S protein can be a breakthrough in vaccine design and development.
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