Selected article for: "severe acute respiratory syndrome patient and syndrome patient"
Author: Ziegler, Katharina; Steininger, Philipp; Ziegler, Renate; Steinmann, Jörg; Korn, Klaus; Ensser, Armin
Title: SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene
  • Cord-id: ilkkj7su
  • Document date: 2020_10_1
    • ID: ilkkj7su
    Snippet: We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.
    Document: We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.

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