Author: Mascolo, Dina; Barba, Pasquale; De Berardinis, Piergiuseppe; Di Rosa, Francesca; Del Pozzo, Giovanna
Title: Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response Cord-id: xyaducmp Document date: 2007_6_1
ID: xyaducmp
Snippet: The Ovalbumin(257–264) CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously eithe
Document: The Ovalbumin(257–264) CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously either single or multiple epitopes and can elicit a cellular response carrying very little peptide (<1.5 µg).
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