Author: Leiva, Rosana; Gazzarrini, Sabrina; Esplugas, Roser; Moroni, Anna; Naesens, Lieve; Sureda, Francesc X.; Vázquez, Santiago
Title: Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog Cord-id: ddhylzid Document date: 2015_3_4
ID: ddhylzid
Snippet: Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
Document: Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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