Selected article for: "intradermal vaccine delivery and vaccine delivery"
Author: Kuwentrai, Chaiyaporn; Yu, Jinming; Rong, Li; Zhang, Bao‐Zhong; Hu, Ye‐Fan; Gong, Hua‐Rui; Dou, Ying; Deng, Jian; Huang, Jian‐Dong; Xu, Chenjie
Title: Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
  • Cord-id: im21lzpu
  • Document date: 2020_12_12
    • ID: im21lzpu
    Snippet: The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional b
    Document: The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.

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