Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_75_1
Snippet: ow the limit of detection (dotted lines). (D) Histogram of frequencies of intrahost SNV identified in the spinal cords of 12 mice from panel D (7 infected with WT and 5 infected with 3DG64S). Black, synonymous or noncoding; blue, nonsynonymous. (E) Survival curves showing mice with paralysis free survival over time for groups (n=43 per virus combined from two experiments, see Table S2 ) infected intramuscularly with 10^6 pfu of 3DG64S (dashed blu.....
Document: ow the limit of detection (dotted lines). (D) Histogram of frequencies of intrahost SNV identified in the spinal cords of 12 mice from panel D (7 infected with WT and 5 infected with 3DG64S). Black, synonymous or noncoding; blue, nonsynonymous. (E) Survival curves showing mice with paralysis free survival over time for groups (n=43 per virus combined from two experiments, see Table S2 ) infected intramuscularly with 10^6 pfu of 3DG64S (dashed blue), or 3DG64S ; 2CV127L (orange). ** p<0.005, by Log rank test, actual p value 0.0012. (F) Survival curves showing mice with paralysis free survival over time for groups (n=43 per virus combined from two experiments, see Table S2 ) infected intramuscularly with 10^6 pfu of 3DG64S (dashed blue), or 3DG64S ; I92T ; K276R (pink) *p<0.05 by Log rank test, actual p value 0.0411.
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