Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_83
Snippet: We solved for the two unknown variables: (i) n, the number of deleterious sites in the genome, 902 and (ii) c, the fitness cost of the G64S mutation in the absence of mutational load, which is 903 relative to the wild type (arbitrarily set to 1). Because there are two unknown variables, we need 904 two equations to solve for them. We use the measured relative fitness in the absence of ribavirin 905 and the ribavirin concentration where the relati.....
Document: We solved for the two unknown variables: (i) n, the number of deleterious sites in the genome, 902 and (ii) c, the fitness cost of the G64S mutation in the absence of mutational load, which is 903 relative to the wild type (arbitrarily set to 1). Because there are two unknown variables, we need 904 two equations to solve for them. We use the measured relative fitness in the absence of ribavirin 905 and the ribavirin concentration where the relative fitness is expected to be 1 (150µM, see Fig.
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