Author: Gloria P. Larson; Vy Tran; Shuiqìng Yú; Yíngyún Caì; Christina A. Higgins; Danielle M. Smith; Steven F. Baker; Sheli R. Radoshitzky; Jens H. Kuhn; Andrew Mehle
Title: EPS8 facilitates uncoating of influenza A virus Document date: 2019_3_28
ID: muq5rkaa_26
Snippet: EGFR has previously been implicated in FLUAV entry during virion internalization (Eierhoff et al., 2010) . Our data, however, indicate that loss of wildtype EPS8 does not alter attachment and that bypassing internalization by forcing fusion at the plasma membrane does not rescue defects in these cells (Figure 3 ), suggesting EPS8 activity is independent of EGFR signaling. EPS8 is also involved in modulating actin dynamics (Hertzog et al., 2010) ......
Document: EGFR has previously been implicated in FLUAV entry during virion internalization (Eierhoff et al., 2010) . Our data, however, indicate that loss of wildtype EPS8 does not alter attachment and that bypassing internalization by forcing fusion at the plasma membrane does not rescue defects in these cells (Figure 3 ), suggesting EPS8 activity is independent of EGFR signaling. EPS8 is also involved in modulating actin dynamics (Hertzog et al., 2010) . Actin has been implicated in the rapid movement of virion-containing endosomes immediately after virion internalization and also plays a role in the discrete steps post-fusion but before uncoating is completed (Banerjee et al., 2014; Lakadamyali et al., 2003) . A role for actin during post-fusion uncoating is the same step where our data revealed EPS8 functions, raising the possibility that it is the ability of EPS8 to engage and modulate actin dynamics that is important for uncoating.
Search related documents:
Co phrase search for related documents- cell defect and plasma membrane: 1, 2
Co phrase search for related documents, hyperlinks ordered by date