Author: Gloria P. Larson; Vy Tran; Shuiqìng Yú; Yíngyún Caì; Christina A. Higgins; Danielle M. Smith; Steven F. Baker; Sheli R. Radoshitzky; Jens H. Kuhn; Andrew Mehle
Title: EPS8 facilitates uncoating of influenza A virus Document date: 2019_3_28
ID: muq5rkaa_5
Snippet: Here, we conducted a screen using gene correlation analysis to identify host factors involved in FLUAV infection. Gene correlation analysis exploits naturally occurring variations in gene expression across multiple cell lines without the need to exogenously manipulate the cellular environment. Variations in cellular gene expression were used to identify factors affecting a phenotype of interest, in this case susceptibility to FLUAV infection. We .....
Document: Here, we conducted a screen using gene correlation analysis to identify host factors involved in FLUAV infection. Gene correlation analysis exploits naturally occurring variations in gene expression across multiple cell lines without the need to exogenously manipulate the cellular environment. Variations in cellular gene expression were used to identify factors affecting a phenotype of interest, in this case susceptibility to FLUAV infection. We identified epidermal growth factor receptor (EGFR) pathway substrate 8 (EPS8) as a pro-viral cellular cofactor during the early stages of infection. We confirmed that EPS8 enhances FLUAV gene expression and replication, whereas knockout of EPS8 reduced susceptibility to infection.
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