Author: Gao, Feng; Zheng, Kenneth I; Wang, Xiaoâ€Bo; Yan, Huaâ€Dong; Sun, Qingâ€Feng; Pan, Keâ€Hua; Wang, Tingâ€Yao; Chen, Yongâ€Ping; George, Jacob; Zheng, Mingâ€Hua
Title: Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients Cord-id: iiniecga Document date: 2020_6_5
ID: iiniecga
Snippet: BACKGROUND AND AIM: Coronavirus disease 2019 (COVIDâ€19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVIDâ€19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVIDâ€19 severity in nondiabetic patients was investigated here. METHODS: The study cohort comprised 65 patients with (i.e. cases) and 65 patients
Document: BACKGROUND AND AIM: Coronavirus disease 2019 (COVIDâ€19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVIDâ€19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVIDâ€19 severity in nondiabetic patients was investigated here. METHODS: The study cohort comprised 65 patients with (i.e. cases) and 65 patients without MAFLD (i.e. controls). Each case was randomly matched with one control by sex (1:1) and age (±5 years). The association between the presence of MAFLD (as exposure) and COVIDâ€19 severity (as the outcome) was assessed by binary logistic regression analysis. RESULTS: In nondiabetic patients with COVIDâ€19, the presence of MAFLD was associated with a fourâ€fold increased risk of severe COVIDâ€19; the risk increased with increasing numbers of metabolic risk factors. The association with COVIDâ€19 severity persisted after adjusting for age, sex, and coexisting morbid conditions. CONCLUSION: Healthâ€care professionals caring for nondiabetic patients with COVIDâ€19 should be cognizant of the increased likelihood of severe COVIDâ€19 in patients with MAFLD.
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