Author: Da, B. L.; Suchman, K.; Roth, N.; Rizvi, A.; Vincent, M.; Trindade, A. J.; Bernstein, D.; Satapathy, S. K.
Title: Cholestatic liver injury in COVIDâ€19 is a rare and distinct entity and is associated with increased mortality Cord-id: ioakgcsw Document date: 2021_4_23
ID: ioakgcsw
Snippet: Current evidence indicates that the development of acute hepatocellular liver injury during coronavirus disease 2019 (COVID-19) is associated with more severe COVID-19 disease.[1] Since SARS-CoV2 is able to enter the liver via the ACE2 receptor proteins located on the epithelium of bile ducts, direct viral cholangiocyte injury is theoretically a possible pathogenic mechanism of the virus resulting in cholestatic liver injury.[2] Supporting this idea: a recent meta-analysis that reported serum al
Document: Current evidence indicates that the development of acute hepatocellular liver injury during coronavirus disease 2019 (COVID-19) is associated with more severe COVID-19 disease.[1] Since SARS-CoV2 is able to enter the liver via the ACE2 receptor proteins located on the epithelium of bile ducts, direct viral cholangiocyte injury is theoretically a possible pathogenic mechanism of the virus resulting in cholestatic liver injury.[2] Supporting this idea: a recent meta-analysis that reported serum alkaline phosphatase (ALP) elevations occurs in up to 13.7% of patients[3], a case series describing the clinical/histologic features of three patients with COVID-19 cholangiopathy[4], and a recent study reporting higher fatality rates in COVID-19 patients with cholestasis.[5].
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