Selected article for: "influenza laboratory test and laboratory test"
Author: Yi Han; Haidong Zhang; Sucheng Mu; Wei Wei; Chaoyuan Jin; Yuan Xue; Chaoyang Tong; Yunfei Zha; Zhenju Song; Guorong Gu
Title: Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients
  • Document date: 2020_3_27
    • ID: 54o2p36a_19
    Snippet: Among the risk factors we investigated in this study, we surprisingly discovered that LDH had the most positive relationship between both PSI and CT score. In addition, it was also most positively relevant to APACHE II and SOFA scores, which reflected a strong correlation between LDH with lung damage as well as disease severity. LDH is a major player in glucose metabolism which is present in tissues throughout the body and catalyzes pyruvate to l.....
    Document: Among the risk factors we investigated in this study, we surprisingly discovered that LDH had the most positive relationship between both PSI and CT score. In addition, it was also most positively relevant to APACHE II and SOFA scores, which reflected a strong correlation between LDH with lung damage as well as disease severity. LDH is a major player in glucose metabolism which is present in tissues throughout the body and catalyzes pyruvate to lactate. It is released from cells upon damage of their cytoplasmic membrane (10) . Previous studies also had noted the importance of LDH as an indicator of lung diseases. In a study on Epstein-Barr virus (EBV), researchers found that EBV infected B cells had more LDH transcripts than the uninfected B cells (11) . In addition, the serum levels of LDH increased in PcP patients, probably was due to lung injury (12, 13) . Among patients who were infected during the 2009 influenza A (H1N1) pandemic, 77.8% whose laboratory test showed LDH > 225U/L had lung involvement, without difference between adult and children (14) , which indicated that LDH elevation was associated with various pathogen including virus, and was relevant to lung injury.

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