Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_37
Snippet: We hypothesized that gene expression from respiratory fluids obtained at the site of infection would distinguish patients with LRTI from those with non-infectious respiratory diseases. To test this idea, we evaluated a priori selected gene biomarkers of innate and adaptive immune responses using the total normalized expression of all genes. Given suspected between-subject immunologic response heterogeneity due to differences in infection type and.....
Document: We hypothesized that gene expression from respiratory fluids obtained at the site of infection would distinguish patients with LRTI from those with non-infectious respiratory diseases. To test this idea, we evaluated a priori selected gene biomarkers of innate and adaptive immune responses using the total normalized expression of all genes. Given suspected between-subject immunologic response heterogeneity due to differences in infection type and degree of immunologic compromise, we created a composite metric based on the sum normalized gene expression of all biomarkers. We found significantly increased expression in patients with confirmed LRTI pathogens versus those without (94.9, IQR 93.8-105.6, n=6 vs. All rights reserved. No reuse allowed without permission.
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