Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_50
Snippet: Our results also demonstrate that both mNGS and conventional methods identify clinically significant and insignificant microbes, and emphasize the need to assess the impact of a given microbiologic finding in the context of a patient's immunologic response (5) . Expression of a multi-gene immune response metric was significantly increased in patients with confirmed respiratory pathogens relative to those without, suggesting that despite significa.....
Document: Our results also demonstrate that both mNGS and conventional methods identify clinically significant and insignificant microbes, and emphasize the need to assess the impact of a given microbiologic finding in the context of a patient's immunologic response (5) . Expression of a multi-gene immune response metric was significantly increased in patients with confirmed respiratory pathogens relative to those without, suggesting that despite significant and heterogeneous states of immune suppression, HCT recipients still exhibited immunologic biomarkers of active infection (p=0.022, Figure 3 ).
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