Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_51
Snippet: Amongst subjects with potential new pathogens, we observed that two of the three HRV-A positive subjects demonstrated the lowest expression of this immune response metric, while the remaining subject, who was co-infected with HRV-A and Stenotrophomonas maltophilia, had one of the highest values. This is consistent with prior reports demonstrating that HRV can induce a broad range of clinical disease severity, and that viral-bacterial co-infection.....
Document: Amongst subjects with potential new pathogens, we observed that two of the three HRV-A positive subjects demonstrated the lowest expression of this immune response metric, while the remaining subject, who was co-infected with HRV-A and Stenotrophomonas maltophilia, had one of the highest values. This is consistent with prior reports demonstrating that HRV can induce a broad range of clinical disease severity, and that viral-bacterial co-infection can increase the severity of disease (48, 49) . Amongst subjects with confirmed pathogens, the patient with clinically suspected HHV-6 pneumonitis was notably an outlier in terms of reduced immune metric expression and elevated airway diversity. The respiratory pathogenicity of HHV-6 is controversial, and our paired mNGS pathogen data demonstrating absence of viral All rights reserved. No reuse allowed without permission.
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