Large-scale analysis of redox-sensitive conditionally disordered protein regions reveal their widespread nature and key roles in high-level eukaryotic processes

Gábor Erdos; Bálint Mészáros; Dana Reichmann; Zsuzsanna Dosztányi

These molecular and network level processes enable characteristic cellular functions that are typically centered around cell movement, growth, differentiation, and proliferation. The majority of these processes require the coordination between various pathways and utilize several . CC-BY-NC 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/412692 doi: bioRxiv preprint molecular processes. As a result, these processes typically show very little preference for either of the two types of redox-sensitive structural switches. The two main exceptions to this rule are cell movement via chemotaxis, which mostly involves mostly disulfide bonded extracellular proteins, and stem cell division and population maintenance, mostly relying on metal ion coordinating cysteine clusters.