Selected article for: "de novo infection and novo infection"
Author: Kwang Su Kim; Keisuke Ejima; Yusuke Ito; Shoya Iwanami; Hirofumi Ohashi; Yoshiki Koizumi; Yusuke Asai; Shinji Nakaoka; Koichi Watashi; Robin N Thompson; Shingo Iwami
Title: Modelling SARS-CoV-2 Dynamics: Implications for Therapy
  • Document date: 2020_3_27
    • ID: 09r4d3nu_15
    Snippet: virus production), the induction of cytotoxicity had relatively mild effects on the AUC 176 reduction if initiated before peak viral load. However, cytotoxicity induction initiated 177 after peak viral load could effectively reduce the viral load AUC (Fig. 3CF) . This 178 implies that there is an optimal time to apply this therapy, and that significant antiviral 179 effects are expected unless the promoting rate is too low or therapy is initiated.....
    Document: virus production), the induction of cytotoxicity had relatively mild effects on the AUC 176 reduction if initiated before peak viral load. However, cytotoxicity induction initiated 177 after peak viral load could effectively reduce the viral load AUC (Fig. 3CF) . This 178 implies that there is an optimal time to apply this therapy, and that significant antiviral 179 effects are expected unless the promoting rate is too low or therapy is initiated either 180 too early or too late. However, large reductions of target cells due to ongoing de 181 novo infection cannot be avoided even with very early initiation (i.e., immediately 182 after symptom onset) of the therapy. 183 All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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