Selected article for: "different virus and give virus"

Author: Dauber, Bianca; Wolff, Thorsten
Title: Activation of the Antiviral Kinase PKR and Viral Countermeasures
  • Cord-id: iuf0kd20
  • Document date: 2009_10_27
  • ID: iuf0kd20
    Snippet: The interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2α-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as dsRNA, the canonical activator of PKR, has not been detected in cells infected with such viruses. In this review we focus on the activating RNA molecules of different virus families, in particular the negative-strand RNA viruses. We discuss the
    Document: The interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2α-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as dsRNA, the canonical activator of PKR, has not been detected in cells infected with such viruses. In this review we focus on the activating RNA molecules of different virus families, in particular the negative-strand RNA viruses. We discuss the recently identified non-canonical activators 5′-triphosphate RNA and the vRNP of influenza virus and give an update on strategies of selected RNA and DNA viruses to prevent activation of PKR.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activation dimerization: 1
    • absence presence and activation dsrna: 1
    • absence presence and activation loop: 1
    • absence presence and activity lack: 1, 2, 3, 4, 5
    • access open and activity lack: 1
    • activate pkr and long dsrna: 1
    • activation dsrna and long dsrna: 1, 2