Association between thiamine deficiency and hyperlactatemia among critically ill patients with diabetes infected by SARS‐CoV‐2

Gonçalves, Sandra Elisa Adami Batista; Gonçalves, Thiago José Martins; Guarnieri, Andreia; Risegato, Rodrigo Cristovão; Guimarães, Maysa Penteado; de Freitas, Daniella Cabral

BACKGROUND: The present study aims to verify the association between diabetes and thiamine deficiency in critically ill patients infected by severe acute respiratory syndrome coronavirus 2. METHODS: This is a descriptive cross‐sectional study, whose demographic, anthropometric, and laboratory data (arterial lactate, bicarbonate, and plasma thiamine) were obtained in the first hours of admission to the intensive care unit. Patients with diabetes were compared with individuals without diabetes, and the correlation was performed between thiamine and lactate levels. Thiamine levels <28 μg/L were considered as thiamine deficiency. RESULTS: Overall, 270 patients met the inclusion criteria; 51.1% were men, and the median age was 74 years (66.8‐81). The median value of thiamine was 54.0 μg/L (38‐72.3), and 15.6% had thiamine deficiency. Among patients with diabetes, 26.3% had thiamine deficiency, and 69.3% had hyperlactatemia. There was an association between thiamine deficiency and diabetes (odds ratio 4.28; 95% CI, 2.08‐8.81; P < .001). There was a strong negative correlation between thiamine and arterial lactate in patients with diabetes (r = −0.711, P < .001) and a moderate negative correlation in critically ill patients without diabetes (r = −0.489, P < .001). CONCLUSIONS: The prevalence of thiamine deficiency in critically ill patients due to coronavirus disease 2019 is higher in patients with diabetes. There is a negative correlation between thiamine and arterial lactate levels, which is higher in people with diabetes.