Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins and clotting factors for transfusion support in patients with hematologic disease

Nair, Prajeeda M.; Rendo, Matthew J.; Reddoch-Cardenas, Kristin M.; Burris, Jason K.; Meledeo, Michael A.; Cap, Andrew P.

Hematologic diseases include a broad range of acquired and congenital disorders, many of which affect plasma proteins that control hemostasis and immune responses. Therapeutic interventions for these disorders include transfusion of plasma, cryoprecipitate, immunoglobulins, or convalescent plasma-containing therapeutic antibodies from patients recovering from infectious diseases, as well as concentrated pro- or anticoagulant factors. This review will focus on recent advances in the uses of plasma and its derivatives for patients with acquired and congenital hematologic disorders.